CalmEze Plus Equine (1.5kg)

CalmEze Plus Equine is a powder for horses which is used as a nutritional aid in managing anxiety related conditions.

Common stressors in horses include:

• Box rest
• Sickness and pain
• Change in environment
• Boxing and travelling
• Inappropriate riding or use
• Competition
• Grooming, shoeing and dental work

Directions for use:

WEIGHT	POWDER	PASTE
Foals, Weanlings, Ponies <250 kg	½ Sachet (25 g)	10 ml
Horses <500 kg	½ Sachet (25 g)	20 ml
Large Horses >500 kg	1 Sachet (50 g)	25 ml

For long-term use, speak to your veterinarian.
Can be mixed into the horse’s feed. Administer one to two hours before the stressful event or activity.
Can be repeated if desired effect is not achieved.
if the period of stress is longer than one day, then continue with once daily dosing for the duration of stressful period.

Active ingredients:

L-TRYPTOPHAN
A precursor of serotonin, which controls behaviour and mood. It has been observed that low levels of serotonin are directly related to aggression, depression and stress.”
PEPTAZINE®
A hydrolysed peptide with benzodiazepine-like effects and sympathoadrenal activity. It promotes increased levels of GABA in the hippocampus and hypothalamas, thereby reducing anxiety.
L-THEANINE
Increases the levels of GABA, which is essential for the control of central nervous system responses during periods of fear and anxiety. It also helps to increase serotonin and dopamine levels and reduces cortisol and noradrenaline levels.
N-ACETYL TAURINATE MAGNESIUM
Magnesium is a vital macromineral essential for cellular health and function and is essential in the regulation of vascular tone and heart rhythm. It plays an important role in reducing nerve excitability and muscle spasms. Studies found a correlation between nervousness and sub optimal levels of magnesium in the diet.
THIAMINE (Vitamin B1)
An essential dietary requirement and is important for energy metabolism within the central nervous system. It has been shown to reduce anxiety and improve general well-being. Deficiencies can cause selective loss of neurons, cholinergic neurotransmitter function impairment and can lead to generalised anxiety disorder.
NIACIN (Vitamin B3)
The key mediator for neuronal development and survival during oxidative stress.
Deficiencies can cause dementia, depression and neuro degenerative-like symptoms. Niacin has been indicated as a treatment for ischaemic and traumatic injuries, psychiatric disorders and neurological diseases.
PYRIDOXINE (Vitamin B6)
Pyridoxine is an essential co-factor for the conversion of 5-HTP into serotonin and has been shown to increase the transport of tryptophan into serotonergic neurons, thereby increasing serotonin synthesis. Deficiencies can lead to a reduced number of serotonin-2 receptor sites.